Epidemiology cohort vs case-control studies exam review

This flashcard set reviews key concepts and terminology related to epidemiology cohort and case-control studies, focusing on their definitions, differences, advantages, and disadvantages.

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Cohort study definition?

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A research design that follows a group (cohort) over time to assess outcomes.

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Quiz(24 questions)

Question 1 of 24

1. What is the primary objective of a cohort study?

Terms in this Study Set(24)

Flashcards 1(12)

Cohort study definition?

A research design that follows a group (cohort) over time to assess outcomes.

Case-control study process?

Starts with outcomes, identifies cases, then compares to controls.

True or False: Cohort studies are always retrospective.

False. Cohort studies can be prospective or retrospective.

Fill in the blank: In a cohort study, ____ are followed over time.

participants

Comparison: Cohort vs Case-Control studies.

Cohort studies: follow subjects forward. Case-control: look backward at exposures.

Advantages of cohort studies?

- Can establish time sequence - Observe multiple outcomes - Less recall bias

Disadvantages of case-control studies?

- Recall bias - Cannot determine incidence - Requires clear case definitions

When to use a case-control study?

Use when outcomes are rare or when studying multiple exposures.

What is a risk ratio?

Risk ratio (RR) compares the probability of an outcome in two groups: RR = P(event∣exposed)P(event∣unexposed)\displaystyle \frac{P(event|exposed)}{P(event|unexposed)}.

Example of a cohort study?

Study smokers vs non-smokers over 10 years for lung cancer incidence.

Purpose of matching in case-control studies?

To control for confounding variables by ensuring cases and controls are similar.

True or False: Case-control studies provide direct measures of incidence.

False. They estimate associations, not direct incidence rates.

Flashcards 2(12)

Cohort study advantages?

1. Can establish incidence. 2. Follows over time. 3. Less recall bias.

Case-control studies: strengths?

1. Quick and cost-effective. 2. Good for rare diseases. 3. Requires fewer subjects.

True or False: Cohort studies are always prospective.

False: They can be prospective or retrospective.

Fill in the blank: In a case-control study, we start with ____ and look for exposure.

cases (disease status)

Cohort vs Case-control: main difference?

Cohort studies start with exposure; case-control starts with disease.

Cause → Effect: Cohort study example?

Smoking (cause) → Lung cancer (effect) assessed over time.

What is a major bias in case-control studies?

Recall bias: participants may not accurately remember past exposures.

Define 'confounding variable'.

A variable that influences both the exposure and outcome, potentially skewing results.

What statistical measure compares odds in case-control studies?

Odds Ratio (OR): compares odds of exposure in cases vs controls.

True or False: Cohort studies can assess multiple outcomes.

True: They can evaluate various health outcomes related to the exposure.

Case-control studies use which sampling method?

They often use 'matching' to pair cases with controls based on characteristics.

What is a limitation of cohort studies?

They require large sample sizes and long follow-up periods, increasing costs.

Questions in this Study Set(24)

1. What is the primary objective of a cohort study?

A.To assess outcomes over time in a defined group
B.To analyze past exposures in individuals
C.To identify risk factors after an outcome occurs
D.To conduct interviews with participants

2. Which of the following is an advantage of cohort studies?

A.Can establish incidence
B.Is less time-consuming
C.Requires fewer subjects
D.Always starts with disease

3. What characterizes a case-control study?

A.It follows participants over a period.
B.It compares individuals with a specific outcome to those without.
C.It is only conducted prospectively.
D.It requires random assignment of participants.

4. What is a primary benefit of case-control studies?

A.Assess multiple exposures
B.Evaluate rare diseases
C.Establish temporality
D.Always prospective

5. True or False: Cohort studies are typically less expensive than case-control studies.

A.True
B.False
C.Only in large populations
D.Only if conducted retrospectively

6. True or False: Cohort studies can only be prospective.

A.True
B.False
C.Depends on the disease
D.Always retrospective

7. In a cohort study, what is typically measured over time?

A.Exposures only
B.Outcomes such as disease incidence
C.Demographics
D.Medical history only

8. In a case-control study, researchers look for exposure among which group?

A.Healthy controls
B.All participants
C.Cases
D.Random population

9. Which of the following statements is true about cohort studies?

A.They can establish a time sequence of events.
B.They are ideal for studying rare diseases.
C.They rely on recall for data collection.
D.They are always retrospective.

10. What distinguishes cohort studies from case-control studies?

A.Cohorts start with disease
B.Cohorts track exposures over time
C.Case-controls assess incidence
D.Case-controls follow participants

11. What is a limitation of case-control studies?

A.They can measure incidence rates directly.
B.They require a large sample size.
C.They are susceptible to recall bias.
D.They follow subjects over time.

12. Which scenario illustrates a cause-and-effect relationship in a cohort study?

A.Diet → Heart disease assessed retrospectively
B.Physical activity → Weight loss over time
C.Genetics → Cancer examined cross-sectionally
D.Symptoms → Treatment associations

13. When might a researcher choose to conduct a case-control study?

A.When diseases are common in the population.
B.When evaluating long-term effects of exposures.
C.When studying rare diseases or multiple exposures.
D.When randomization is possible.

14. What is a common bias associated with case-control studies?

A.Selection bias
B.Surveillance bias
C.Recall bias
D.Confounding bias

15. What does the risk ratio (RR) represent?

A.The proportion of a sample that experiences an outcome
B.The comparison of probabilities of an outcome in exposed vs. unexposed groups
C.The total number of cases in a population
D.The average time until an outcome occurs

16. Define 'confounding variable'.

A.A random error in data
B.A variable affecting both exposure and outcome
C.A type of bias
D.An extraneous variable

17. Which scenario best illustrates the cohort study design?

A.Comparing lung cancer rates between smokers and non-smokers over time.
B.Asking individuals about past health events to find out what caused their disease.
C.Tracking patients diagnosed with diabetes and their treatment outcomes.
D.Analyzing existing health records for trends in heart disease.

18. Which statistical measure is commonly used in case-control studies?

A.Relative risk
B.Prevalence ratio
C.Odds Ratio (OR)
D.Incidence rate

19. What is the main purpose of matching in case-control studies?

A.To ensure cases and controls are the same age
B.To minimize the effects of confounding variables
C.To increase the number of cases
D.To reduce the cost of the study

20. True or False: Cohort studies can only study one outcome at a time.

A.True
B.False
C.Depends on study design
D.Only in large cohorts

21. True or False: Case-control studies can provide direct measures of incidence rates.

A.True
B.False
C.Only if using large samples
D.Only when combined with cohort studies

22. What sampling method is commonly used in case-control studies?

A.Stratified sampling
B.Matching
C.Cluster sampling
D.Random sampling

23. Which study design is best suited for investigating rare diseases?

A.Case-control study
B.Cohort study
C.Cross-sectional study
D.Randomized controlled trial

24. What is a limitation of cohort studies?

A.Less expensive
B.Requires large sample sizes
C.Quick to conduct
D.Always prospective

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